Important Vitamins For Helping With Memory

Everyone experiences some cognitive decline with age leading to some memory loss or poor recall. It is a natural process and will occur at different rates for everybody. However, there are many things you can do to help support your brain function and help improve mild cognitive decline including vitamins to support your memory. Let’s have a look at the best memory support supplements and lifestyle recommendations for a healthy ageing brain.

Vitamin B6, Folate and Vitamin B12

If you are looking for vitamins that help support memory, there is some evidence* to show that vitamin B6, folate (vitamin B9) and vitamin B12 may help mild cognitive decline from getting worse. There are several ways these B group vitamins may help with memory and concentration. First, they may assist in decreasing raised homocysteine levels in the body, which has been implicated in cognitive impairment. Second, a deficiency in these nutrients has been seen in those with cognitive decline and third, they are involved in the production of neurotransmitters which can impact mood, sleep and concentration. Lastly, they also aid in energy production in the body which can in turn aid focus and concentration. (5,6,7,8,9,10,11)

Ginkgo biloba

One of the oldest living tree species in the world, Ginkgo has a long tradition in Chinese medicine. This is probably one of the best known memory supplements.  It has been shown to assist with memory, cognitive function, concentration and mental alertness by increasing blood flow to the brain. Ginkgo is best taken for a minimum of 12 weeks to see the benefits. (1)

Bacopa Monnieri

Better known as brahmi, this is another old, traditional herb that has been used in Ayurvedic medicine since around 800 BC. It has clinical studies* that support its ability to enhance memory, with the belief the effects are due to an increase in certain enzymes in the brain leading to the production of new proteins. (2,3,4)

Omega-3 Fatty Acids

Better cognitive performance has been exhibited with the use of omega-3 fatty acids; a diet lacking in omega-3 may cause the brain to age faster leading to cognitive decline. There is also some research* to suggest omega-3 will enhance the cognitive effects of B-vitamins. Omega-3 fatty acids are commonly found in fish and are made up of two components – DHA and EPA. DHA is predominantly found in the brain and thus recommended for brain health; however both EPA and DHA play a role in maintaining cognitive health. In general, western diets are lacking in this essential fat, so make sure you are eating your recommended 2-3 serves of fish a week. (12,13,14,15,16)

Panax ginseng

Used in Traditional Chinese Medicine (TCM) for centuries to enhance stamina and attenuate fatigue and stress. Ginseng has also been researched* for its memory enhancing properties with some positive results. Much of the literature has found ginsengs effect on the central nervous system (memory, learning and behaviour) is due to the ginsenoside content of the root of the plant. (17,18,19,20,21,22)

Rhodiola

A well-known adaptogen in Russia and Scandinavia, the root of the Rhodiola plant has been used to enhance work performance, eliminate fatigue, and increase mental alertness. Whilst more research is needed, this plant is showing promise in its use for enhancing cognitive function and reducing mental fatigue and stress. (1,23,24)

Phosphatidylserine (PS)

PS is a component of cell membranes (the outer wall of the cell) where it helps maintain the structure and fluidity of the membranes and also enhances neurotransmitter function. There has been some research* to suggest PS can be protective of the brain and some trials* have demonstrated it to be beneficial for age-related cognitive decline. (25,26,27,28,29)

Lifestyle

There is no doubt that certain lifestyle measures can help reduce cognitive decline with age. Whilst we’ve all heard about puzzles to keep your mind active, keeping physically active will also provide benefit. Some recommended activities include:

• Gardening
• Dancing
• Any exercise that improves cardiovascular function
• Socialising with friends and family
• Studying
• Working
• Travel
• Puzzles and board games
• Playing a musical instrument

Reducing stress and maintaining a healthy diet such as the Mediterranean Diet, have also been shown to improve memory and cognition. (30,31,32)

Mild cognitive decline is a normal part of life as our brains age; however any significant memory loss and associated behavioural concerns should be investigated further by your doctor. What has become clear is early intervention is key and can go a long way in minimising normal age related memory decline, so don’t wait! Start incorporating these preventative measures now.

References:

1. Braun, L. & Cohen, M.  2015. Herbs & Natural Supplements: An Evidence Based Guide. 4^th edition. Vol 2. Elsevier Sydney
2. Calebrese, C. et al. 2008. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med, 2008;14(6):707-13.
3. Mathur, D. et. al. 2016. The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera). Front Pharmacol, 2016;7:44
4. Stough, C. et. al. 2015. Mechanisms, Efficacy, and Safety of Bacopa monnieri (Brahmi) for Cognitive and Brain Enhancement. Evid Based Complement Alternat Med, 2015;2015717605
5. Ebadi, M. 1981. Regulation and function of pyridoxal phosphate in CNS. Neurochemistry International Vol 3, Issues 3-4, 1981, pp 181-205
6. Malouf, R. et. al. 2003. The effect of vitamin B6 on cognition. Cochrane Database Sys Rev. 2003;(4):CD004393
7. Deijen, J.B. et. al. 1992. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology Dec 1992, Vol 109, Issue 4, pp 489-496
8. Calvaresi, E. Bryan, J. 2001. B Vitamins, Cognition, and Aging: A Review. The Journals of Gerontology: Series B, Volume 56, Issue 6, 1 November 2001, pp 327-339
9. Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, et al. 2010. Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLoS ONE 5(9): e12244.
10. Agnew-Blais, J.C. Wassertheil-Smoller, S. et. al. 2015. Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study. J Acad Nutr Diet. 2015 Feb; 115(2): 231–241.
11. de Jager, C.A. et. al. 2012. Cognitive and clinical outcomes of homocysteine‐lowering B‐vitamin treatment in mild cognitive impairment: a randomized controlled trial. International Journal of Geriatric Psychiatry, Vol 27, Iss 6, June 2012, pp 592-600.
12. Z. S. Tan, W. S. Harris, A. S. et. al. 2012. Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging. Neurology, 2012; 78 (9): 658
13. Bauer, I. et. al. 2014. Omega-3 supplementation improves cognition and modifies brain activation in young adults. Hum Psychopharmacol. 2014 Mar;29(2):133-44.
14. Kulzow, N. et. al. 2016. Impact of Omega-3 Fatty Acid Supplementation on Memory Functions in Healthy Older Adults. J Alzheimers Dis. 2016;51(3):713-25
15. Jaremka, L.M. et. al. 2014. Omega-3 Supplementation and Loneliness-Related Memory Problems: Secondary Analyses Of A Randomized Controlled Trial. Psychosom Med. 2014 Oct; 76(8): 650–658.
16. Oulhaj, A. et. al. 2016. Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. Journal of Alzheimer's Disease, vol. 50, no. 2, pp. 547-557, 2016
17. Soon-Tae, L. et. al. 2008. Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease. Alzheimer Disease & Associated Disorders: July-September 2008 - Volume 22 - Issue 3 - p 222-226
18. Gillis, C.N. 1997. Panax ginseng pharmacology: A nitric oxide link? Biochemical Pharmacology Volume 54, Issue 1, 1 July 1997, Pages 1-8
19. Choi. K. 2008. Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer. Acta Pharmacologica Sinica Vol 29, Iss 9, September 2008, pp1109-1118
20. Petkov, V.D. Kehayov, R. et. al. 1993. Memory Effects of Standardized Extracts of Panax ginseng (G115), Ginkgo biloba (GK 501) and their Combination Gincosan® (PHL-00701). Planta Med 1993; 59(2): 106-114
21. Reay, J.L. Kennedy, D.O. Scholey, A.B. 2005. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. Journal of Psychopharmacology, Volume: 19 issue: 4, page(s): 357-365
22. Cho, I. 2012. Effects of Panax ginseng in Neurodegenerative Diseases. J Ginseng Res. 2012 Oct; 36(4): 342–353.
23. Olsson, E.M.G. von Scheele, B. Panossian, A.G. 2009. A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Standardised Extract SHR-5 of the Roots of Rhodiola rosea in the Treatment of Subjects with Stree-Related Fatigue. Planta Med 2009; 75: 105-112
24. Brown, R.P. Gerbarg, P.L. Ramazanov, Z. 2002. Rhodiola rosea A Phytomedicinal Overview. HerbalGram 56; 2002
25. Vakhapova, V. Cohen, T. et. al. 2014. Phosphatidylserine Containing Omega-3 Fatty Acids May Improve Memory Abilities in Nondemented Elderly Individuals with Memory Complaints: Results from an Open-Label Extension Study. Dement Geriatr Cogn Disord 2014;38:39-45
26. Kidd PM. 1999. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev. 1999;4:144-161.
27. Ott BR, Owens NJ. 1998. Complementary and alternative medicines for Alzheimer's disease. J Geriatr Psychiatry Neurol. 1998;11:163-173.
28. Crook, T.H. Tinklenberg, J. 1991. Effects of phosphatidylserine in age‐associated memory impairment. Neurology May 1991, 41 (5) 644-649.
29. Richter, Y. Herzog, Y. 2013. The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin Interv Aging. 2013; 8: 557–563.
30. Harada, C.N. et. al. Normal Cognitive Aging. Clin Geriatr Med. 2013 Nov; 29(4): 737–752.
31. Alzheimer’s Disease Research Center. 2017. Cognitive Skills & Normal Aging. Emory University. Viewed 31/8/18. http://alzheimers.emory.edu/healthy_aging/cognitive-skills-normal-aging.html
32. Deary, I.J. Corley, J. et. al. 2009. Age-associated cognitive decline. British Medical Bulletin, Volume 92, Issue 1, 1 December 2009, Pages 135–152